Effect of chlormadinone acetate, a synthetic progesterone, on hypoxic ventilatory response in men.

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Effect of chlormadinone acetate, a synthetic progesterone, on hypoxic ventilatory response in men.

Ten healthy young males were studied with a double-blind, cross-over trial to determine whether or not chlormadinone acetate (CMA), a potent synthetic progesterone, augments hypoxic chemosensitivity. Seven days after CMA administration, inspiratory minute volume (VI) and tidal volume (VT) significantly increased. PaCO2 decreased by 3.0 +/- 2.6 (S.D.) Torr (p less than 0.05) and plasma bicarbona...

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The ventilatory response to hypoxia depends on the pattern and intensity of hypoxic exposure and involves several physiological mechanisms. These mechanisms differ in their effect (facilitation or depression) on different components of ventilation (tidal volume and frequency) and in their time course (seconds to years). Some mechanisms last long enough to affect future ventilatory responses to ...

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ژورنال

عنوان ژورنال: The Japanese Journal of Physiology

سال: 1987

ISSN: 1881-1396,0021-521X

DOI: 10.2170/jjphysiol.37.137